“Scientists at the University of Southampton have discovered a potential and novel way of preventing asthma at the origin of the disease, a finding that could challenge the current understanding of the condition. The research, published in The Journal of Clinical Investigation (JCI) Insight, analysed the impact of the gene ADAM33, which is associated with the development of asthma. ADAM33 makes an enzyme, which is attached to cells in the airway muscles. When the enzyme loses its anchor to the cell surface, it is prone to going rogue around the lung causing poorer lung function in people who have asthma.”
“The studies in human tissue samples and mice, led by Hans Michel Haitchi, Associate Professor in Respiratory Medicine at the University of Southampton, suggests that if you switch off ADAM33 or prevent it from going rouge, the features of asthma — airway remodelling (more muscle and blood vessels around the airways), twitchiness and inflammation — will be reduced.”This finding radically alters our understanding of the field, to say the least,” says Professor Haitchi. “For years we have thought that airway remodelling is the result of the inflammation caused by an allergic reaction, but our research tells us otherwise.”
Read the full article: Stop the rogue ADAM gene and you stop asthma
Recent Posts
- The American Health Council Appoints Dr. James Bashkin, D.Phil. to the Physician Board March 31, 2020
- The American Health Council Appoints Dr. Robert W. Letton, MD to the Physician Board March 19, 2020
- The American Health Council Appoints Dr. Akwasi Adjei to the Industry Board January 17, 2020
- The American Health Council Appoints Dr. Nelson Leung to the Physician Board January 17, 2020
- The American Health Council Appoints Ms. Karie Soost to the Physician Board January 17, 2020
- The American Health Council Appoints Mr. Gregory King to the Industry Board January 17, 2020
