A new finding revealed about HIV, and it’s entry mechanism into the immune cell nucleus. This finding suggests that this could lead to a new type of anti-HIV drug that could help slow down the HIV process, in hopes that the immune system would be able to kill the virus.
“Once HIV enters an immune cell, it has to make its way into the nucleus to fuse with the cell’s DNA. Most viruses wait until the cell divides to do this, but HIV is too impatient. Instead, the virus hijacks a protein and makes it enlarge pores in the membrane surrounding the nucleus that the cell uses to pass materials to and from the nucleus.”
“The discovery that Prof. Campbell and colleagues make in their study surrounds a protein called KIF5B that normally transports various materials inside the cell away from the nucleus. They found that HIV-1 hijacks KIF5B and induces it to tear off pieces of the nuclear envelope and transport them away from the nucleus, causing the pores to become big enough to allow HIV-1 to pass through. The pieces that are torn off are proteins called Nup358.”
Read the full article: HIV entry mechanism into immune cell nucleus revealed
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