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Why Lab-Made Stem Cells Might Fail: Errors in DNA Folding | American Health Council

Why Lab-Made Stem Cells Might Fail: Errors in DNA Folding

Why Lab-Made Stem Cells Might Fail: Errors in DNA Folding - Health Council

“Induced pluripotent stem cells hold promise for regenerative medicine because they can, in theory, turn into any type of tissue and because they are made from a patient’s own adult cells, guaranteeing compatibility. However, the technique that turns adult cells into these iPS cells is not foolproof; after reverting to their pluripotent state, these cells don’t always correctly differentiate back into adult cells.”

“Researchers from the University of Pennsylvania have now discovered one of the reasons why: the reversion process does not always fully capture the way a cell’s genome is folded up inside its nucleus. This folding configuration directly influences gene expression and therefore the functionality of the cell.”

Read the full article: Why lab-made stem cells might fail: Errors in DNA folding